Another highly regulated enzyme in glycolysis is phosphofructokinase (PFK1). There is evidence from some tumors that PFK1 undergoes a posttranslational proteolysis that yields a truncated functional enzyme (47 kD vs 85 kD) that is insensitive to citrate and ATP. How might this work and why would it be beneficial for a tumor cell?

Chapt 7 – , Sociology In Our Times
September 11, 2021
Criminal Justice Scenario
September 11, 2021

Another highly regulated enzyme in glycolysis is phosphofructokinase (PFK1). There is evidence from some tumors that PFK1 undergoes a posttranslational proteolysis that yields a truncated functional enzyme (47 kD vs 85 kD) that is insensitive to citrate and ATP. How might this work and why would it be beneficial for a tumor cell?

1. Hexokinase II (the isoform usually discussed in biochemistry classes as part of glycolysis) catalyzes the first step in glycolysis. The isoform of hexokinase that is expressed in most tumor cells is bound to the mitochondrial outer membrane facing the cytosol. Propose two reasons why this would be beneficial to the tumor cell.

2. Another highly regulated enzyme in glycolysis is phosphofructokinase (PFK1). There is evidence from some tumors that PFK1 undergoes a posttranslational proteolysis that yields a truncated functional enzyme (47 kD vs 85 kD) that is insensitive to citrate and ATP. How might this work and why would it be beneficial for a tumor cell?


 


The post Another highly regulated enzyme in glycolysis is phosphofructokinase (PFK1). There is evidence from some tumors that PFK1 undergoes a posttranslational proteolysis that yields a truncated functional enzyme (47 kD vs 85 kD) that is insensitive to citrate and ATP. How might this work and why would it be beneficial for a tumor cell? appeared first on nursing assignment tutor.

"Is this question part of your assignment? We Can Help!"

Essay Writing Service